Jnk

What does it do? JNK is important for sending signals from the cell membrane to nuclear transcription factors, increasing their ability to activate transcription. JNK signalling has been implicated in cell growth, oncogenic transformation, cell differentiation and cell death. Stimuli that activate JNK include growth factors, cytokines and just about any kind of stress (see Figure). JNK can be turned off by dual specificity MAPK phosphatases (MKPs), which often function in a negative feedback loop.